Additional, community-made monster sets are also available for players to download, incorporating enemy rosters from the likes of Half-Life, Marathon and Heretic, to sets that don't even have a representative fighter, such as System Shock and Chex Quest. QC:DE comes packaged with several monster sets, which the player can enable/disable at their leisure to replace existing enemies spawned on any given map with those from Doom II (the default set), DOOM (2016), Quake, Quake II and Quake IV. However, the game is also PvE compatible players can play through almost any compatible Megawad (including the official Doom campaigns) solo or as a party. QC:DE is primarily a PvP mod, offering a variety of Solo and Team game types including Deathmatch, Capture The Flag, Domination, Last Man Standing, Survival and Freeze Tag. However, QC:DE brings a new roster of 31 Champions to the fray, as well as the BFG10K, a weapon that isn't present in the game it's inspired from.

It aims to emulate the gameplay and features of Quake Champions, not only porting its arsenal, but also the Champions system: the ability to play as a character with a weight class, an active ability and one or two passive abilities. Other compatible source ports include Zandronum 3.0, GZDoom 1.8.6-3.2.5 and Delta Touch.

The mod comes packaged with the dedicated Q-Zandronum source port, which offers Quake-styled movement, improved netcode and a variety of other quality-of-life changes. Quake Champions: Doom Edition is a Game Mod for Doom created by DBThanatos and Michaelis and released on February 6, 2018. 'Sometimes the world doesn't need another hero.

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